transgenic app23 mice Search Results


app23 mice  (Institute for Clinical Pharmacodynamics)
90
Institute for Clinical Pharmacodynamics app23 mice
Insoluble protein extracts from aged wild-type mouse brains seed Aβ aggregation in vitro . Lag times measured for Aβ aggregation in the presence of 0.001 μg detergent-insoluble protein extracts from wild-type mouse brains at different ages. Mean values (red lines) with respective SEM of three biological replicates (each including five technical replicates) from on average 2.7, 18.7, and 26.7 month-old mouse brain insoluble extracts. Lag time of an 18 month-old mouse brain soluble extract (sol, negative control) and a 20 month-old mouse brain insoluble extract from an <t>APP23</t> transgenic mouse (APP23, positive control). One-way ANOVA: 2.7 months vs. 18.7 months ∗∗ p = 0.0073, 2.7 months vs. 26.7 months ∗∗ p = 0.0067.
App23 Mice, supplied by Institute for Clinical Pharmacodynamics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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app23 mouse line  (Jackson Laboratory)
86
Jackson Laboratory app23 mouse line
Aged Tg <t>APP23</t> mice have higher numbers of hypointense lesions on MGE 9.4 T MRI compared to WT littermates: (a) a representative example of an MGE image in a 24-month-old Tg APP23 male mouse, showing three cortical (white squares) and one deep (orange square) hypointense lesions, (b) the number of cortical hypointense lesions on MGE MRI was higher in the Tg mice compared to the WT littermates (β = 2.57 (95% CI: 1.45–3.86), z = 4.25, p < 0.001), and (c) the number of deep hypointense lesions on MGE MRI was also higher in the Tg mice compared to the WT littermates (β = 1.24 (95% CI: 0.50–2.02), z = 3.37, p < 0.001). These effects are corrected for age and sex using a negative binomial regression model ( n = 29 mice). Circles and triangles indicate female and male mice, respectively. MGE: multi-gradient echo; WT: wildtype; Tg: transgenic.
App23 Mouse Line, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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app23 mouse line - by Bioz Stars, 2026-09
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genetic background  (Jackson Laboratory)
86
Jackson Laboratory genetic background
Aged Tg <t>APP23</t> mice have higher numbers of hypointense lesions on MGE 9.4 T MRI compared to WT littermates: (a) a representative example of an MGE image in a 24-month-old Tg APP23 male mouse, showing three cortical (white squares) and one deep (orange square) hypointense lesions, (b) the number of cortical hypointense lesions on MGE MRI was higher in the Tg mice compared to the WT littermates (β = 2.57 (95% CI: 1.45–3.86), z = 4.25, p < 0.001), and (c) the number of deep hypointense lesions on MGE MRI was also higher in the Tg mice compared to the WT littermates (β = 1.24 (95% CI: 0.50–2.02), z = 3.37, p < 0.001). These effects are corrected for age and sex using a negative binomial regression model ( n = 29 mice). Circles and triangles indicate female and male mice, respectively. MGE: multi-gradient echo; WT: wildtype; Tg: transgenic.
Genetic Background, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mice  (Jackson Laboratory)
86
Jackson Laboratory mice
Aged Tg <t>APP23</t> mice have higher numbers of hypointense lesions on MGE 9.4 T MRI compared to WT littermates: (a) a representative example of an MGE image in a 24-month-old Tg APP23 male mouse, showing three cortical (white squares) and one deep (orange square) hypointense lesions, (b) the number of cortical hypointense lesions on MGE MRI was higher in the Tg mice compared to the WT littermates (β = 2.57 (95% CI: 1.45–3.86), z = 4.25, p < 0.001), and (c) the number of deep hypointense lesions on MGE MRI was also higher in the Tg mice compared to the WT littermates (β = 1.24 (95% CI: 0.50–2.02), z = 3.37, p < 0.001). These effects are corrected for age and sex using a negative binomial regression model ( n = 29 mice). Circles and triangles indicate female and male mice, respectively. MGE: multi-gradient echo; WT: wildtype; Tg: transgenic.
Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sappa/sappb multiplex assay multi-spot 4  (Meso Scale Diagnostics LLC)
90
Meso Scale Diagnostics LLC sappa/sappb multiplex assay multi-spot 4
Aged Tg <t>APP23</t> mice have higher numbers of hypointense lesions on MGE 9.4 T MRI compared to WT littermates: (a) a representative example of an MGE image in a 24-month-old Tg APP23 male mouse, showing three cortical (white squares) and one deep (orange square) hypointense lesions, (b) the number of cortical hypointense lesions on MGE MRI was higher in the Tg mice compared to the WT littermates (β = 2.57 (95% CI: 1.45–3.86), z = 4.25, p < 0.001), and (c) the number of deep hypointense lesions on MGE MRI was also higher in the Tg mice compared to the WT littermates (β = 1.24 (95% CI: 0.50–2.02), z = 3.37, p < 0.001). These effects are corrected for age and sex using a negative binomial regression model ( n = 29 mice). Circles and triangles indicate female and male mice, respectively. MGE: multi-gradient echo; WT: wildtype; Tg: transgenic.
Sappa/Sappb Multiplex Assay Multi Spot 4, supplied by Meso Scale Diagnostics LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cd68/sr-d1 antibody (fa-11) - bsa free  (Bio-Techne corporation)
94
Bio-Techne corporation cd68/sr-d1 antibody (fa-11) - bsa free
Aged Tg <t>APP23</t> mice have higher numbers of hypointense lesions on MGE 9.4 T MRI compared to WT littermates: (a) a representative example of an MGE image in a 24-month-old Tg APP23 male mouse, showing three cortical (white squares) and one deep (orange square) hypointense lesions, (b) the number of cortical hypointense lesions on MGE MRI was higher in the Tg mice compared to the WT littermates (β = 2.57 (95% CI: 1.45–3.86), z = 4.25, p < 0.001), and (c) the number of deep hypointense lesions on MGE MRI was also higher in the Tg mice compared to the WT littermates (β = 1.24 (95% CI: 0.50–2.02), z = 3.37, p < 0.001). These effects are corrected for age and sex using a negative binomial regression model ( n = 29 mice). Circles and triangles indicate female and male mice, respectively. MGE: multi-gradient echo; WT: wildtype; Tg: transgenic.
Cd68/Sr D1 Antibody (Fa 11) Bsa Free, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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app23 transgenic mice  (Novartis)
86
Novartis app23 transgenic mice
Aged Tg <t>APP23</t> mice have higher numbers of hypointense lesions on MGE 9.4 T MRI compared to WT littermates: (a) a representative example of an MGE image in a 24-month-old Tg APP23 male mouse, showing three cortical (white squares) and one deep (orange square) hypointense lesions, (b) the number of cortical hypointense lesions on MGE MRI was higher in the Tg mice compared to the WT littermates (β = 2.57 (95% CI: 1.45–3.86), z = 4.25, p < 0.001), and (c) the number of deep hypointense lesions on MGE MRI was also higher in the Tg mice compared to the WT littermates (β = 1.24 (95% CI: 0.50–2.02), z = 3.37, p < 0.001). These effects are corrected for age and sex using a negative binomial regression model ( n = 29 mice). Circles and triangles indicate female and male mice, respectively. MGE: multi-gradient echo; WT: wildtype; Tg: transgenic.
App23 Transgenic Mice, supplied by Novartis, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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phenylmethylsulfonyl fluoride  (Enamine Ltd)
99
Enamine Ltd phenylmethylsulfonyl fluoride
Aged Tg <t>APP23</t> mice have higher numbers of hypointense lesions on MGE 9.4 T MRI compared to WT littermates: (a) a representative example of an MGE image in a 24-month-old Tg APP23 male mouse, showing three cortical (white squares) and one deep (orange square) hypointense lesions, (b) the number of cortical hypointense lesions on MGE MRI was higher in the Tg mice compared to the WT littermates (β = 2.57 (95% CI: 1.45–3.86), z = 4.25, p < 0.001), and (c) the number of deep hypointense lesions on MGE MRI was also higher in the Tg mice compared to the WT littermates (β = 1.24 (95% CI: 0.50–2.02), z = 3.37, p < 0.001). These effects are corrected for age and sex using a negative binomial regression model ( n = 29 mice). Circles and triangles indicate female and male mice, respectively. MGE: multi-gradient echo; WT: wildtype; Tg: transgenic.
Phenylmethylsulfonyl Fluoride, supplied by Enamine Ltd, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Insoluble protein extracts from aged wild-type mouse brains seed Aβ aggregation in vitro . Lag times measured for Aβ aggregation in the presence of 0.001 μg detergent-insoluble protein extracts from wild-type mouse brains at different ages. Mean values (red lines) with respective SEM of three biological replicates (each including five technical replicates) from on average 2.7, 18.7, and 26.7 month-old mouse brain insoluble extracts. Lag time of an 18 month-old mouse brain soluble extract (sol, negative control) and a 20 month-old mouse brain insoluble extract from an APP23 transgenic mouse (APP23, positive control). One-way ANOVA: 2.7 months vs. 18.7 months ∗∗ p = 0.0073, 2.7 months vs. 26.7 months ∗∗ p = 0.0067.

Journal: Frontiers in Aging Neuroscience

Article Title: Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation

doi: 10.3389/fnagi.2017.00138

Figure Lengend Snippet: Insoluble protein extracts from aged wild-type mouse brains seed Aβ aggregation in vitro . Lag times measured for Aβ aggregation in the presence of 0.001 μg detergent-insoluble protein extracts from wild-type mouse brains at different ages. Mean values (red lines) with respective SEM of three biological replicates (each including five technical replicates) from on average 2.7, 18.7, and 26.7 month-old mouse brain insoluble extracts. Lag time of an 18 month-old mouse brain soluble extract (sol, negative control) and a 20 month-old mouse brain insoluble extract from an APP23 transgenic mouse (APP23, positive control). One-way ANOVA: 2.7 months vs. 18.7 months ∗∗ p = 0.0073, 2.7 months vs. 26.7 months ∗∗ p = 0.0067.

Article Snippet: Wild-type C57BL/6J (WT) and transgenic APP23 mice ( ) were bred and maintained under pathogen-free conditions at the Hertie Institute for Clinical Brain Research.

Techniques: In Vitro, Negative Control, Transgenic Assay, Positive Control

Aged Tg APP23 mice have higher numbers of hypointense lesions on MGE 9.4 T MRI compared to WT littermates: (a) a representative example of an MGE image in a 24-month-old Tg APP23 male mouse, showing three cortical (white squares) and one deep (orange square) hypointense lesions, (b) the number of cortical hypointense lesions on MGE MRI was higher in the Tg mice compared to the WT littermates (β = 2.57 (95% CI: 1.45–3.86), z = 4.25, p < 0.001), and (c) the number of deep hypointense lesions on MGE MRI was also higher in the Tg mice compared to the WT littermates (β = 1.24 (95% CI: 0.50–2.02), z = 3.37, p < 0.001). These effects are corrected for age and sex using a negative binomial regression model ( n = 29 mice). Circles and triangles indicate female and male mice, respectively. MGE: multi-gradient echo; WT: wildtype; Tg: transgenic.

Journal: Journal of Cerebral Blood Flow & Metabolism

Article Title: Neuropathological correlates of MRI-observed hypointense lesions in the APP23 mouse model of cerebral amyloid angiopathy

doi: 10.1177/0271678X261424057

Figure Lengend Snippet: Aged Tg APP23 mice have higher numbers of hypointense lesions on MGE 9.4 T MRI compared to WT littermates: (a) a representative example of an MGE image in a 24-month-old Tg APP23 male mouse, showing three cortical (white squares) and one deep (orange square) hypointense lesions, (b) the number of cortical hypointense lesions on MGE MRI was higher in the Tg mice compared to the WT littermates (β = 2.57 (95% CI: 1.45–3.86), z = 4.25, p < 0.001), and (c) the number of deep hypointense lesions on MGE MRI was also higher in the Tg mice compared to the WT littermates (β = 1.24 (95% CI: 0.50–2.02), z = 3.37, p < 0.001). These effects are corrected for age and sex using a negative binomial regression model ( n = 29 mice). Circles and triangles indicate female and male mice, respectively. MGE: multi-gradient echo; WT: wildtype; Tg: transgenic.

Article Snippet: The APP23 mouse line is available at Jackson Laboratories (reference number #030504).

Techniques: Transgenic Assay

Histopathological correlates of cortical and deep hypointense lesions: (a) MGE image of a cortical hypointense lesion (white arrow) in a 24-month-old Tg APP23 female mouse that corresponded to an iron-positive microbleed with associated hemosiderin deposits (black arrows on H&E) on histopathology (a’: adjacent PB and H&E stains shown), (b) MGE image of a deep hypointense lesion (white arrow) in a 24-month-old Tg APP23 male mouse that corresponded to an iron-positive microbleed with associated hemosiderin deposits (black arrows on H&E) on histopathology (b’: adjacent PB and H&E stains shown), and (c) MGE image of two deep hypointense lesions (white arrows) in a 24-month-old Tg APP23 female mouse (same as in (a)) that corresponded to calcifications on histopathology (c’: adjacent H&E and VK stains shown). MGE: multi-gradient echo; PB: Perls’ Prussian Blue; H&E: hematoxylin & eosin; VK: Von Kossa.

Journal: Journal of Cerebral Blood Flow & Metabolism

Article Title: Neuropathological correlates of MRI-observed hypointense lesions in the APP23 mouse model of cerebral amyloid angiopathy

doi: 10.1177/0271678X261424057

Figure Lengend Snippet: Histopathological correlates of cortical and deep hypointense lesions: (a) MGE image of a cortical hypointense lesion (white arrow) in a 24-month-old Tg APP23 female mouse that corresponded to an iron-positive microbleed with associated hemosiderin deposits (black arrows on H&E) on histopathology (a’: adjacent PB and H&E stains shown), (b) MGE image of a deep hypointense lesion (white arrow) in a 24-month-old Tg APP23 male mouse that corresponded to an iron-positive microbleed with associated hemosiderin deposits (black arrows on H&E) on histopathology (b’: adjacent PB and H&E stains shown), and (c) MGE image of two deep hypointense lesions (white arrows) in a 24-month-old Tg APP23 female mouse (same as in (a)) that corresponded to calcifications on histopathology (c’: adjacent H&E and VK stains shown). MGE: multi-gradient echo; PB: Perls’ Prussian Blue; H&E: hematoxylin & eosin; VK: Von Kossa.

Article Snippet: The APP23 mouse line is available at Jackson Laboratories (reference number #030504).

Techniques: Histopathology

Microbleeds in Tg APP23 mice show signs of vascular remodeling and lower vascular amyloid-β burden at the rupture site: (a, b) examples of two separate microbleeds that demonstrated signs of vascular remodeling (arrows in (a, b)), and absence of amyloid-β at the presumed rupture site (arrows in (a′, b′)) and (c, d) examples of two separate microbleeds (arrows in (c, d) point at hemosiderin deposits) for which the culprit vessel or the rupture site could not be identified (c′, d′). H&E: hematoxylin & eosin; Aβ: amyloid-β.

Journal: Journal of Cerebral Blood Flow & Metabolism

Article Title: Neuropathological correlates of MRI-observed hypointense lesions in the APP23 mouse model of cerebral amyloid angiopathy

doi: 10.1177/0271678X261424057

Figure Lengend Snippet: Microbleeds in Tg APP23 mice show signs of vascular remodeling and lower vascular amyloid-β burden at the rupture site: (a, b) examples of two separate microbleeds that demonstrated signs of vascular remodeling (arrows in (a, b)), and absence of amyloid-β at the presumed rupture site (arrows in (a′, b′)) and (c, d) examples of two separate microbleeds (arrows in (c, d) point at hemosiderin deposits) for which the culprit vessel or the rupture site could not be identified (c′, d′). H&E: hematoxylin & eosin; Aβ: amyloid-β.

Article Snippet: The APP23 mouse line is available at Jackson Laboratories (reference number #030504).

Techniques:

Remodeled vessels are observed in Tg APP23 mice: (a) an example of a leptomeningeal blood vessel at the level of the pial surface with evidence of vascular remodeling, (b) lower burden of amyloid-β compared to neighboring vessels, (c) deposition of fibrin(ogen) in the wall, suggestive of blood–brain barrier leakage, and (d) perivascular inflammation in the form of Iba-1-positive cells (arrows). H&E: hematoxylin & eosin; Aβ: amyloid-β; Iba-1: ionized calcium-binding adapter molecule 1.

Journal: Journal of Cerebral Blood Flow & Metabolism

Article Title: Neuropathological correlates of MRI-observed hypointense lesions in the APP23 mouse model of cerebral amyloid angiopathy

doi: 10.1177/0271678X261424057

Figure Lengend Snippet: Remodeled vessels are observed in Tg APP23 mice: (a) an example of a leptomeningeal blood vessel at the level of the pial surface with evidence of vascular remodeling, (b) lower burden of amyloid-β compared to neighboring vessels, (c) deposition of fibrin(ogen) in the wall, suggestive of blood–brain barrier leakage, and (d) perivascular inflammation in the form of Iba-1-positive cells (arrows). H&E: hematoxylin & eosin; Aβ: amyloid-β; Iba-1: ionized calcium-binding adapter molecule 1.

Article Snippet: The APP23 mouse line is available at Jackson Laboratories (reference number #030504).

Techniques: Binding Assay

3D visualization of cortical blood vessel in a microbleed region: (a) MGE image of microbleed in a 24-month-old Tg APP23 male mouse, (b) MGE image co-registered to 3D Lightsheet microscopy image in region of microbleed. Box surrounding vessel shown in (c/d). Vessel with discontinuity (arrow) in which no amyloid-β, SMA, or Glut1 staining was observed (c, d). Rotation of blood vessel in 3D is shown in Supplemental Movie 1 . MGE: multi-gradient echo; SMA: smooth muscle actin; Glut1: glucose transporter 1.

Journal: Journal of Cerebral Blood Flow & Metabolism

Article Title: Neuropathological correlates of MRI-observed hypointense lesions in the APP23 mouse model of cerebral amyloid angiopathy

doi: 10.1177/0271678X261424057

Figure Lengend Snippet: 3D visualization of cortical blood vessel in a microbleed region: (a) MGE image of microbleed in a 24-month-old Tg APP23 male mouse, (b) MGE image co-registered to 3D Lightsheet microscopy image in region of microbleed. Box surrounding vessel shown in (c/d). Vessel with discontinuity (arrow) in which no amyloid-β, SMA, or Glut1 staining was observed (c, d). Rotation of blood vessel in 3D is shown in Supplemental Movie 1 . MGE: multi-gradient echo; SMA: smooth muscle actin; Glut1: glucose transporter 1.

Article Snippet: The APP23 mouse line is available at Jackson Laboratories (reference number #030504).

Techniques: Microscopy, Staining